January 2017 Science Bulletin: Major US NTP review finds PFCs to be immunotoxic

January 16, 2017 at 1:12 pm | Posted in Uncategorized | Leave a comment

PFCs, immunotoxicity | Immunotoxicity Associated with Exposure to Perfluorooctanoic Acid (PFOA) or Perfluorooctane Sulfonate (PFOS).The NTP concludes that both PFOA and PFOS are presumed to be an immune hazard to humans based on a high level of evidence from animal studies that PFOA and PFOS suppressed the antibody response and a moderate level of evidence from studies in humans. The evidence that these chemicals affect multiple aspects of the immune system supports the overall conclusion that both PFOA and PFOS alter immune functions in humans.

Phthalates, fertility | Parental contributions to early embryo development: influences of urinary phthalate and phthalate alternatives among couples undergoing IVF treatment. Our results suggest an inverse association between male preconception concentrations of select phthalate metabolites and blastocyst quality, likely occurring after genomic activation. If corroborated with other studies, such findings will have public health and clinical significance for both the general population and those undergoing IVF.

Cancer prevention | Cancer Prevention During Early Life. CDC’s Division of Cancer Prevention and Control sponsored a special issue in the journal Pediatrics about factors from before birth through early childhood that may affect a person’s chance of getting cancer. The authors of papers in this issue are experts from many different professions, showing the importance of working together to address potential cancer causes and risk factors.

Air pollution, cardiovascular disease | Air pollution and cardiovascular mortality with over 25years follow-up: A combined analysis of two British cohorts. Adverse effects of air pollution on cardiovascular disease (CVD) mortality are well established. There are comparatively fewer studies in Europe, and in the UK particularly, than in North America. We examined associations in two British cohorts with >25years of follow-up. Elevated non-significant hazard ratios for CVD mortality were seen with 1991 BS and SO2 and with ESCAPE PM10 and PM2.5 in fully adjusted linear models.

POPs exposure during weight loss | Increased blood levels of persistent organic pollutants (POP) in obese individuals after weight loss-A review. Most research in this field, including animal studies, is carried out on a single compound or group of selected compounds, not taking the “cocktail effect” into consideration. This does not reflect the true range of POP to which humans are actually exposed. Few chronic investigations have been published and, in particular, few studies were available that compared the increase in POP concentrations with clinical consequences as individuals lost weight. These limitations call for caution in interpreting results. The benefits of losing weight still far outweigh the potential adverse health risks. However, further studies are recommended to determine the clinical significance of increased blood levels of POPs following rapid and excessive weight loss, particularly for women attending weight reduction treatment before pregnancy.

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