September 2016 Science Bulletin: Pesticides and wheeze; the value of investigating air pollution and still birth

September 15, 2016 at 3:20 pm | Posted in News and Science Bulletins | Leave a comment

September 2016 Science Bulletin

Pesticides, allergies | Pesticides Are Associated with Allergic and Non-Allergic Wheeze among Male Farmers. In models evaluating current use of specific pesticides, 19 pesticides were significantly associated (p<0.05) with allergic wheeze (18 positive, 1 negative) and 21 pesticides with non-allergic wheeze (19 positive, 2 negative); 11 pesticides with both. Seven pesticides and a fungicide had significantly different associations for allergic and non-allergic wheeze. In exposure-response models with up to five exposure categories, we saw evidence of an exposure-response relationship for several pesticides including the commonly used herbicides 2,4-D and glyphosate, the insecticides permethrin and carbaryl and the rodenticide warfarin.

BPA, obesity | Perinatal BPA exposure alters body weight and composition in a dose specific and sex specific manner: the addition of peripubertal exposure exacerbates adverse effects in female mice. Both perinatal exposure alone and perinatal plus peripubertal exposure to environmentally relevant levels of BPA resulted in lasting effects on body weight and body composition. The effects were dose specific and sex specific and were influenced by the precise window of BPA exposure.

POPs, obesity | Early-Life Exposures to Persistent Organic Pollutants in Relation to Overweight in Preschool Children. Maternal serum concentrations of HCB, PFOS and PFOA were associated with increased BMI z-scores and/or overweight risk (i.e. BMI z-score≥ 85th WHO percentile). No clear association was found for maternal serum-PCBs, p,p’-DDE, PFHxS, PFNA and PFDA. In cross-sectional analyses, we observed a pattern of inverse associations between child serum-POPs and BMI z-scores at age 5, perhaps due to reverse causation that requires attention in future prospective analyses. Findings in this recent cohort support a role of maternal exposure to endocrine disruptors in the childhood obesity epidemic.

Air pollution, still birth | Is it still important to study if ambient air pollution triggers stillbirth? Stillbirth is one of the most neglected tragedies in global health today, and the existing evidence, summarised by Siddika et al, deserves additional investigation. Although the reported summary effect estimates were relatively small, the ubiquitous nature of ambient air pollution exposure suggests that exposure to ambient air pollution may have a large population-attributable risk for stillbirth.

BPA, potential alternatives | Wreaking Reproductive Havoc One Chemical at a Time. New variations on bisphenol A seem an awful lot like the original. New results are confirming that suspicion.

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