August science bulletin: PFCs affect thyroid hormone levels in newborn girls; metabolic changes from environmental chemicals

August 8, 2016 at 5:22 pm | Posted in News and Science Bulletins | Leave a comment

August 2016 Science Bulletin

Thyroid disruption, PFCs | Prenatal exposure to perfluorinated compounds affects thyroid hormone levels in newborn girls. Thus, prenatal PFC exposure may disrupt thyroid hormone homeostasis. Thyroid hormones play a crucial role in fetal development and may have gender specific action. Hence, these results are of utmost importance in high-risk groups, such as pregnant women and children.

Metabolic changes, environmental chemicals | Developmental Exposure to Environmental Chemicals and Metabolic Changes in Children. Prenatal exposure to EDCs, particularly the persistent organic pollutant DDT and its metabolite DDE, may influence growth patterns during infancy and childhood. The altered growth patterns associated with EDCs vary according to exposure level, sex, exposure timing, pubertal status, and age at which growth is measured. Early exposure to air pollutants also is linked to impaired metabolism in infants and children. As a result of these and other studies, professional health provider societies have called for a reduction in environmental chemical exposures. We summarize the resources available to health care providers to counsel patients on how to reduce chemical exposures.

Fetal growth, pesticides | Prenatal Exposure to Organophosphorous Pesticides and Fetal Growth: Pooled Results from Four Longitudinal Birth Cohort Studies. This study confirms previously reported associations of prenatal OP exposure among black women with decreased infant size at birth, but finds no evidence of smaller birth weight, length, or head circumference among whites or Hispanics.

Food contact materials, chemical exposure | Printed paper and board food contact materials as a potential source of food contamination. 613 of 1,095 substances in the FACET food contact materials database are registered under REACH, and up to 59 of these are found in the European Chemicals Agency’s (ECHA) Community Rolling Action Plan (CoRAP) list. 18 of the registered substances are present in the Candidate List of substances of very high concern (SVHCs), and 2 are included in Annex XIV (intended for phase-out) due to their toxic effects on reproduction. One has been restricted since June 2010.

Obesity, flame retardants | Perinatal triphenyl phosphate exposure accelerates type 2 diabetes onset and increases adipose accumulation in UCD-type 2 diabetes mellitus rats. Perinatal TPhP exposure increased body and fat mass in 3.5 month old male and female rats, while leptin and cumulative energy intake were elevated in males and females, respectively. Independent of body mass, perinatal TPhP exposure accelerated T2DM onset in males and increased plasma non-esterified- fasting fatty acids. These observations suggest that perinatal exposure to TPhP exacerbates the development of obesity in male and female UCDavis-T2DM rats and accelerates T2DM onset in male UCD-T2DM rats.

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