June 2016 Science Bulletin: antimicrobials increase risk of adverse birth outcomes; how to define EDCs

June 13, 2016 at 12:03 pm | Posted in News and Science Bulletins | Leave a comment

June 2016 Science Bulletin

Development, triclosan | Association of birth outcomes with fetal exposure to parabens, triclosan and triclocarban in an immigrant population in Brooklyn, New York. This study provides the first evidence of associations between antimicrobials and potential adverse birth outcomes in neonates. Findings are consistent with animal data suggesting endocrine-disrupting potential resulting in developmental and reproductive toxicity.

Lou Gehrig’s Disease, POPs | Association of Environmental Toxins With Amyotrophic Lateral Sclerosis. In this study, persistent environmental pollutants measured in blood were significantly associated with ALS and may represent modifiable ALS disease risk factors.

Thyroid disease, flame retardants | PBDE flame retardants, thyroid disease, and menopausal status in U.S. women. Exposure to BDEs 47, 99, and 100 is associated with thyroid disease in a national sample of U.S. women, with greater effects observed post-menopause, suggesting that the disruption of thyroid signaling by PBDEs may be enhanced by the altered estrogen levels during menopause.

Defining “endocrine disrupter” | Scientific Issues Relevant to Setting Regulatory Criteria to Identify Endocrine Disrupting Substances in the European Union. There is scientific agreement regarding the adequacy of the WHO definition of EDs. The potency concept is not relevant to the identification of particularly serious hazards such as EDs. As is common practice for carcinogens, mutagens and reproductive toxicants, a multi-level classification of ED based on the WHO definition, and not considering potency, would be relevant (corresponding to option 3 proposed by the European Commission).

Obesity, BPA | Bisphenol A promotes adiposity and inflammation in a nonmonotonic dose-response way in five-week old male and female C57BL/6J mice fed a low-calorie diet. In this study, we found that five-week-old male and female C57BL/6J mice exposed to four dosages of BPA (5, 50, 500 and 5000 μ g/kg/day) by oral intake for 30 days showed significantly increased body weight and fat mass in a nonmonotonic dose-dependent manner when fed a chow diet (CD). The effect occurred even at the lowest concentration (5μ g/kg/day), lower than the tolerable daily intake (TDI) of 50 μ g/kg/day for BPA.

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