May 2016 Science Bulletin: BPA exposure shows unpredictable effects at low doses

May 20, 2016 at 3:15 pm | Posted in News and Science Bulletins | Leave a comment

May 2016 Science Bulletin

BPA, mammary gland development | Low-dose effects of bisphenol A on mammary gland development in rats. The present findings support data from the published literature showing that perinatal exposure to BPA can induce increased mammary growth and proliferative lesions in rodents. Our results indicate that low-dose exposure to BPA can affect mammary gland development in male and female rats, although higher doses show a different pattern of effects.

BPA, reproductive health | Low-dose effect of developmental bisphenol A exposure on sperm count and behaviour in rats. The present study, using a robust experimental study design, has shown that developmental exposure to 25 μg/kg bw/day bisphenol A can cause adverse effects on fertility (decreased sperm count), neurodevelopment (masculinization of spatial learning in females) and lead to increased female body weight late in life. These results suggest that the new EFSA temporary tolerable daily intake of 4 μg/kg bw/day is not sufficiently protective with regard to endocrine disrupting effects of bisphenol A in humans.

Organophosphates, lung function | Urinary Dialkyl Phosphate Concentrations and Lung Function Parameters in Adolescents and Adults: Results from the Canadian Health Measures Survey. The negative association between ΣDAP and lung function in adult participants suggests a detrimental effect of OP pesticides on lung function in the adult general population. Further studies using prospective designs are warranted to confirm the findings reported in this study.

Pesticides, leukaemia | Residential exposure to pesticides and childhood leukaemia: a systematic review and meta-analysis. Our findings support the assumption that residential pesticide exposure may be a contributing risk factor for childhood leukaemia but available data were too scarce for causality ascertainment. It may be opportune to consider preventive actions, including educational measures, to decrease the use of pesticides for residential purposes and particularly the use of indoor insecticides during pregnancy.

Parabens, endocrine disruption | Multiple endocrine disrupting effects in rats perinatally exposed to butylparaben. Butylparaben exerted endocrine disrupting effects on both male and female offspring. The observed adverse developmental effect on sperm count at the lowest dose is highly relevant to risk assessment, as this is the lowest observed adverse effect level in a study on perinatal exposure to butylparaben.

Phthalates, metabolic syndrome | The association between phthalates and metabolic syndrome: the National Health and Nutrition Examination Survey 2001-2010. Higher concentrations of certain phthalate metabolites were associated with an increased odds of metabolic syndrome (MetS). Higher DEHP metabolite concentrations were associated with an increased odds of MetS for men. In women, the strongest association was between higher concentrations of MBzP and MetS, but only among pre-menopausal women.

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