Feb 2016 Science Bulletin: Organophosphates increase risk of impaired behaviour, neurodegenerative diseases, & other research

February 9, 2016 at 6:44 pm | Posted in Uncategorized | Leave a comment

Human research

Organophosphate pesticides, neurobehavioural performance | A 10-month prospective study of organophosphorus pesticide exposure and neurobehavioral performance among adolescents in Egypt. Changes in neurobehavioral performance across the application season indicate a pattern of impaired performance in the high exposure group compared to the low exposure group. Deficits increased during the application season and remained even months after application ceased. This study is the first to examine the impact of changes in pesticide exposure and neurobehavioral performance not only before and after the application season, but also within the application season.

Organophosphate pesticides, neurodegenerative disease | Organophosphate pesticide exposure and neurodegeneration. Here we review the main neurological and/or cognitive deficits described and the experimental and epidemiological relationships found between pesticide exposure and Alzheimer’s, Parkinson’s, and Amyotrophic Lateral Sclerosis (ALS) diseases.

Organophosphate pesticides, mental health | Assessing the connection between organophosphate pesticide poisoning and mental health: A comparison of neuropsychological symptoms from clinical observations, animal models and epidemiological studies. The purpose of this review is to examine the biological foundations for the epidemiological observations previously identified by reviewing the toxicology literature and relating it to epidemiological studies addressing the role of poisoning with organophosphate pesticides (OPs) in neurobehavioral and neuropsychological disorders. The goal of this review is to raise awareness in the mental health community about the possibility that affective disorders might be the result of contributions from environmental and occupational pesticide poisoning.

Flame retardants, exposure routes | Inhalation a significant exposure route for chlorinated organophosphate flame retardants. Total intake of ClOPFRs via the inhalation exposure route was estimated to exceed intake via dust ingestion, indicating that inhalation is an important route that should be taken into consideration in assessments of these compounds.

Flame retardants, decreased exposure | PBDE levels in breast milk are decreasing in California. Using the same sample extraction procedures and analytical instrumentation method (GC-HRMS), we compared PBDE as well as PCB levels in these breast milk samples to those from our previous study (n = 82, sampled during 2003-2005) and found that the sum of PBDEs over the 7 year course declined by 39%. Our study confirmed that breastfeeding babies are still exposed to high levels of PBDEs, even though PBDE levels are decreasing.

Other research

BPA, reproductive health | The effects of in utero bisphenol A exposure on the ovaries in multiple generations of mice. In utero BPA exposure did not have transgenerational effects on germ cell nest breakdown and gene expression on PND 4, but it caused transgenerational changes in expression in multiple genes on PND 21. Collectively, these data indicate that in utero BPA exposure has some transgenerational effects in mice.

Flame retardants, endocrine disruption | Organophosphate Flame Retardants act as Endocrine-Disrupting Chemicals in MA-10 Mouse Tumor Leydig Cells. All the OPFRs tested affected mitochondrial activity, cell survival, and superoxide production. Basal or stimulated steroid secretion was affected by all of the OPFRs except triphenyl phosphate production; BDE-47 had no effect. Hence, the OPFRs currently used as alternatives affect Leydig cells to a greater extent than the brominated flame retardants that they have replaced.

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