December 2015 Science Bulletin: pesticides and precocious puberty; BPA and hypospadia; and more

December 14, 2015 at 12:15 pm | Posted in News and Science Bulletins | Leave a comment

December 2015 Science Bulletin

Pesticides, Parkinson’s Disease | Association of Parkinson’s Disease and Its Subtypes with Agricultural Pesticide Exposures in Men: A Case-Control Study in France. This study helps to better characterize different aspects of pesticide exposure associated with PD, and shows a significant association of pesticides with tremor-dominant PD in men, the most typical PD presentation.

Pesticides, puberty | Prepubertal Serum Concentrations of Organochlorine Pesticides and Age at Sexual Maturity in Russian Boys. Higher prepubertal serum HCB and βHCH concentrations were associated with a later age at attainment of sexual maturity. Only the highest quartile of serum p,p´-DDE was associated with later pubic hair maturation.

BPA, genital malformations | Bisphenol A and other phenols in human placenta from children with cryptorchidism or hypospadias. The aim of this case-control study was to explore the relationship between exposure to non-persistent EDCs during pregnancy and male genital development. The multivariable regression analyses indicated a statistically significant association between exposure to BPA and propyl-PB and the risk of malformations [adjusted odd ratio (95% CIs) in the third tertile of exposure: 7.2 (1.5-35.5) and 6.4 (1.2-35.5) for BPA and propyl-PB, respectively].

PFCs, birth weight | Association between perfluorinated compound concentrations in cord serum and birth weight using multiple regression models. Seven PFASs were found in cord serum, PFOA and PFOS being dominant, with mean concentrations of 1.11 and 0.87 ng/mL, respectively. The adjusted birth weight changes (natural log) were -0.14 (95% confidence interval -0.33 to 0.03) for PFOS and -0.03 (95% confidence interval -0.25 to 0.18) for PFOA. None of the PFASs were statistically associated with birth weight in this population.

EDCs, human health | EDC-2: The Endocrine Society’s Second Scientific Statement on Endocrine-Disrupting Chemicals. The Endocrine Society’s Second Scientific Statement on EDCs in full.

Male reproductive health | Male Reproductive Disorders and Fertility Trends: Influences of Environment and Genetic Susceptibility. Based on our review of genetic and environmental factors, we conclude that environmental exposures arising from modern lifestyle, rather than genetics, are the most important factors in the observed trends. These environmental factors might act either directly or via epigenetic mechanisms. In the latter case, the effects of exposures might have an impact for several generations post-exposure. In conclusion, there is an urgent need to prioritize research in reproductive physiology and pathophysiology, particularly in highly industrialized countries facing decreasing populations.

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