October Science Bulletin #1: pregnancy loss and phthalate exposure; pesticides and childhood cancer

October 22, 2015 at 2:14 pm | Posted in News and Science Bulletins | Leave a comment

October Science Bulletin #1
Human research

Pregnancy loss, phthalates | Levels of Phthalate Metabolites in Urine of Pregnant Women and Risk of Clinical Pregnancy Loss. Toxicological studies have shown that phthalate esters (PAEs), a class of widely used and environmentally prevalent chemicals, can increase the abortion rate in animals, but epidemiological evidence is scarce. This study of 300 women provides human evidence that phthalate exposure could be associated with miscarriage, mostly between 5 and 13 weeks of pregnancy.

Pesticides, childhood cancer | Residential Exposure to Pesticide During Childhood and Childhood Cancers: A Meta-Analysis. Results from this meta-analysis indicated that children exposed to indoor insecticides would have a higher risk of childhood hematopoietic cancers. Additional research is needed to confirm the association between residential indoor pesticide exposures and childhood cancers. Meanwhile, preventive measures should be considered to reduce children’s exposure to pesticides at home.

Low infant birth weight, BPA | Maternal urinary bisphenol A levels and infant low birth weight: A nested case-control study of the Health Baby Cohort in ChinaMothers with LBW infants had significantly higher urinary BPA levels (median: 4.70μg/L) than the control mothers (median: 2.25μg/L) (p<0.05). Increased risk of LBW was associated with higher maternal urinary levels of BPA [adjusted odds ratio (OR)=3.13 for the medium tertile, 95% confidence interval (CI): 1.21, 8.08; adjusted OR=2.49 for the highest tertile, 95% CI: 0.98, 6.36]. The association was more pronounced among female infants than among male infants, with a statistical evidence of heterogeneity in risk (p=0.03).

Genital malformation, POPs | Association between levels of persistent organic pollutants in adipose tissue and cryptorchidism in early childhood: a case-control study. Prenatal exposure to PCDD/Fs and PCDD/F-like PCBs may be associated with increased risk for cryptorchidism. Our finding does not exclude the possibility of an association between the exposure to PBDEs and cryptorchidism.

Childhood tremor, POPs | Prenatal exposure to the organophosphate pesticide chlorpyrifos and childhood tremor. Compared to all other children, those with prenatal CPF exposure in the upper quartile range (n=43) were more likely to exhibit mild or mild to moderate tremor (≥1) in either arm (p=0.03), both arms (p=0.02), the dominant arm (p=0.01), and the non-dominant arm (p=0.055). Logistic regression analyses showed significant CPF effects on tremor in both arms, either arm, the dominant arm (p-values <0.05), and the non-dominant arm (p=0.06), after adjustment for sex, age at testing, ethnicity, and medication.

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