September Science Bulletin #2: developmental toxicity research needs; “manufacturing doubt” around EDCs

September 11, 2015 at 12:45 pm | Posted in Uncategorized | Leave a comment

September Science Bulletin #2:
Science policy and non-human research

Developmental toxicity | Life-Long Implications of Developmental Exposure to Environmental Stressors: New Perspectives. Current testing paradigms do not allow proper characterization of developmental risk factors and their interactions. Thus, relevant exposure levels and combinations for testing must be identified from human exposure situations and outcome assessments. Testing of potential underpinning mechanisms and biomarker development require laboratory animal models and in vitro approaches. Only few large-scale birth cohorts exist, and collaboration between birth cohorts on a global scale should be facilitated.

EDCs, science and policy | Manufacturing doubt about endocrine disrupter science – A rebuttal of industry-sponsored critical comments on the UNEP/WHO report “State of the Science of Endocrine Disrupting Chemicals 2012”. We conclude that Lamb et al.’s attempt of deconstructing the UNEP/WHO (2013) report is not particularly erudite and that their critique is not intended to be convincing to the scientific community, but to confuse the scientific data. Consequently, it promotes misinterpretation of the UNEP/WHO (2013) report by non-specialists, bureaucrats, politicians and other decision makers.

Pesticides, public health | GMOs, Herbicides, and Public Health. Genetically modified organisms (GMOs) are not high on most physicians’ worry lists. If we think at all about biotechnology, most of us probably focus on direct threats to human health, such as prospects for converting pathogens to biologic weapons or the implications of new technologies for editing the human germline. But while those debates simmer, the application of biotechnology to agriculture has been rapid and aggressive.

Safer alternatives | Alternatives Assessment Frameworks: Research Needs for the Informed Substitution of Hazardous Chemicals. While alternatives assessment is becoming an important science policy field, there is a need for greater cross-disciplinary collaboration to refine methodologies in support of the informed substitution and design of safer chemicals, materials, and products. Case studies can provide concrete lessons to improve alternatives assessment.

Glyphosate, liver | Transcriptome profile analysis reflects rat liver and kidney damage following chronic ultra-low dose Roundup exposure. A 2-year study in rats administering 0.1 ppb Roundup (50 ng/L glyphosate equivalent) via drinking water (giving a daily intake of 4 ng/kg bw/day of glyphosate) was conducted. A marked increased incidence of anatomorphological and blood/urine biochemical changes was indicative of liver and kidney structure and functional pathology. In order to confirm these findings we have conducted a transcriptome microarray analysis of the liver and kidneys from these same animals.

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