September Science Bulletin #1: Phenols affect age of onset of puberty; PFC exposure via breast milk

September 11, 2015 at 12:26 pm | Posted in News and Science Bulletins | Leave a comment
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September Science Bulletin #1:
Human research

Exposure, PFCs | Breastfeeding as an Exposure Pathway for Perfluorinated Alkylates. Duration of exclusive breastfeeding was associated with increases of most PFAS concentrations by up to 30% per month, with lower increases during partial breast-feeding. In contrast to this main pattern, perfluorohexanesulfonate was not affected by breast-feeding. After cessation of breastfeeding, all serum concentrations decreased.

Puberty, phenols | Environmental phenols and pubertal development in girls. For enterolactone and benzophenone-3, girls experienced breast development 5-6months later, adjusted HR 0.79 (0.64-0.98) and HR 0.80 (0.65-0.98) respectively for the 5th vs 1st quintiles of urinary biomarkers (μg/g-creatinine). Earlier breast development was seen for triclosan and 2,5-dichlorophenol: 4-9months sooner for 5th vs 1st quintiles of urinary concentrations (HR 1.17 (0.96-1.43) and HR 1.37 (1.09-1.72), respectively). Association of breast development with enterolactone, but not the other three phenols, was mediated by body size.

Male fertility, phthalates | Phthalate exposure and reproductive parameters in young men from the general Swedish population. DEHP metabolite levels, particularly urinary mono-(2-ethyl-5-carboxypentyl) phthalate (MECPP), were negatively associated with progressive sperm motility, which was 11 (95% CI: 5.0-17) percentage points lower in the highest quartile of MECPP than in the lowest. Further, men in the highest quartile of the DEHP metabolite monoethylhexyl phthalate had 27% (95% CI: 5.5%-53%) higher HDS than men in the lowest quartile.

Male fertility, EDCs | Human exposure to endocrine disrupting chemicals and fertility: A case-control study in male subfertility patients. Our study in men showed that internal body concentrations of endocrine disrupting chemicals are associated with an increased risk of subfertility together with alterations in hormone levels. The results emphasize the importance to reduce chemicals in the environment in order to safeguard male fertility.

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