August 2015 Science Bulletin #1: POPs exposure hinders neurodevelopment; PFCs reduce bone density; and more

August 6, 2015 at 1:44 pm | Posted in News and Science Bulletins | Leave a comment

August 2015 Science Bulletin #1:
Human Research

Air pollution, mortality | Air Pollution and Mortality in Seven Million Adults: The Dutch Environmental Longitudinal Study (DUELS). After adjustment for individual and area-specific confounders, for each 10-μg/m3 increase, PM10 and NO2 were associated with nonaccidental mortality [hazard ratio (HR) = 1.08; 95% CI: 1.07, 1.09 and HR = 1.03; 95% CI: 1.02, 1.03, respectively], respiratory mortality (HR = 1.13; 95% CI: 1.10, 1.17 and HR = 1.02; 95% CI: 1.01, 1.03, respectively), and lung cancer mortality (HR = 1.26; 95% CI: 1.21, 1.30 and HR = 1.10 95% CI: 1.09, 1.11, respectively). Furthermore, PM10 was associated with circulatory disease mortality (HR = 1.06; 95% CI: 1.04, 1.08).

POPs, infant growth | Prenatal and Postnatal Exposure to Persistent Organic Pollutants and Infant Growth: A Pooled Analysis of Seven European Birth Cohorts. To our knowledge, this is the largest study to date of POPs exposure and infant growth, and it contains state-of-the-art exposure modelling. Prenatal p,p´-DDE was associated with increased infant growth, and postnatal PCB-153 with decreased growth at European exposure levels.

Flame retardants, neurodevelopment | Association between prenatal exposure to polybrominated diphenyl ethers and young children’s neurodevelopment in China. At 12 months of age, neither the individual nor total (the sum of BDEs 47, 99, 100, and 153) congener levels were associated with any of the four domain DQs. However, at 24 months of age, a 10-fold increase in BDE-99 levels was associated with a 2.16-point decrease [95% confidence interval (CI): -4.52, -0.20] in language domain DQs and a 10-fold increase in BDE-47 levels was associated with a 1.89-point decrease (95% CI: -3.75, -0.03) in social domain DQs.

PFCs, bone density | Association of Perfluoroalkyl Substances, Bone Mineral Density, and Osteoporosis in the U.S. Population in NHANES 2009-2010. In a representative sample of the adult US population, serum PFAS concentrations were associated with lower bone mineral density, with variation according to specific PFAS and bone sites assessed. Most associations were limited to women. Osteoporosis in women also was associated with PFAS exposures, based on a small number of cases.

EDCs, hypospadia | Is Hypospadias Associated with Prenatal Exposure to Endocrine Disruptors? A French Collaborative Controlled Study of a Cohort of 300 Consecutive Children without Genetic Defect. This multicenter prospective controlled study with a homogeneous cohort of hypospadiac boys without genetic defects strongly suggests that EDCs are a risk factor for hypospadias through occupational and environmental exposure during fetal life. The association of various types of exposures may increase this risk.

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