May 2015 Science Bulletin #1: BPA and overweight in the elderly; prenatal air pollution and blood pressure; and more

May 12, 2015 at 1:22 pm | Posted in News and Science Bulletins | Leave a comment
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May 2015 Science Bulletin #1
Human research

BPA, overweight | Association of bisphenol A exposure with overweight in the elderly: a panel study. The odds ratio (OR) of overweight was 1.17 (95 % confidence interval [CI] 1.04-1.32) per interquartile range increase of log-transformed BPA. When stratified based on sex, we observed a significant association in women (OR 1.25; 95 % CI 1.09-1.45) but not in men (OR 0.97; 95 % CI 0.77-1.22). The ORs of overweight increased with quartiles of BPA in women (quartile 2 vs 1: OR 1.54; 95 % CI 1.02-2.32, 3 vs 1: OR 1.70; 95 % CI 1.10-2.62, and 4 vs 1: OR 1.81; 95 % CI 1.13-2.92).

Air pollution, blood pressure | Prenatal air pollution exposure and newborn blood pressure. Exposures to PM2.5 and black carbon in late pregnancy were positively associated with newborn systolic blood pressure (SBP), whereas ozone was negatively associated with SBP.

Phthalates, childhood growth | Prenatal Phthalate Exposure and Childhood Growth and Blood Pressure: Evidence from the Spanish INMA-Sabadell Birth Cohort Study. This study suggests that prenatal phthalate exposure may be associated with postnatal growth and blood pressure in a sex-specific manner. Inconsistencies with previous cross-sectional findings highlight the necessity for evaluating phthalate health effects in prospective studies.

POPs, childhood obesity | Association of Prenatal Exposure to Persistent Organic Pollutants with Obesity and Cardiometabolic Traits in Early Childhood: The Rhea Mother-Child Cohort. On multivariable regression analyses, a 10-fold increase in HCB was associated with a higher BMI z score, obesity, abdominal obesity, greater sum of skinfold thickness and higher systolic BP at 4 years of age. Prenatal DDE exposure was associated with higher BMI z score, abdominal obesity and higher diastolic BP. PCBs were not significantly associated with offspring obesity or cardiometabolic risk factors.

Correspondence highlight: pesticide exposure &
risk of neurodevelopmental disorders

Neurodevelopmental Disorders and Agricultural Pesticide Exposures. “Although we commend the investigators’ efforts to identify, recruit, and enroll parents of children with ASDs or DD, absent is any confirmation of exposures or that the active ingredients drifted onto the residences or were inhaled or ingested, let alone at dose levels that might be adverse to the fetus.”

Shelton and Hertz-Picciotto Respond. “Previous work has consistently demonstrated that pesticide drift results in elevated levels of these compounds in both indoor air and house dust in residences located near agricultural applications.”

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