April 2015 Science Bulletin #1: flame retardants in fatter children; pesticides linked to reduced male fertility; and more

April 12, 2015 at 7:08 pm | Posted in News and Science Bulletins | Leave a comment
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April 2015 Science Bulletin #1:
Human Research

Flame retardants, child BMI | In Utero and Childhood Polybrominated Diphenyl Ether Exposures and Body Mass at Age 7 Years: The CHAMACOS Study. We estimated sex-specific associations with maternal PBDE levels during pregnancy and body mass index at age 7 with positive associations in boys and negative associations in girls. Children’s serum BDE-153 concentrations were inversely associated with body mass index at age 7 with no difference by sex. Future studies should examine the longitudinal trends in obesity with PBDE exposure and changes in hormonal environment as children transition through puberty, as well as evaluate the potential for reverse causality.

Pesticides, cardiovascular disease, fat mass | Associations of organochlorine pesticides and polychlorinated biphenyls with total, cardiovascular, and cancer mortality in elders with differing fat mass. The positive association between OC pesticides and CVD mortality was also observed only among elderly with low fat mass. The possibility of interaction between POPs and the amount of fat mass on risk of mortality from chronic diseases is clinically important in modern societies with an obesity epidemic and requires confirmation in other studies with larger sample size.

BPA, neonatal thyroid function | Gestational urinary bisphenol A and maternal and newborn thyroid hormone concentrations: The HOME Study. We observed no significant associations between 16-week BPA and THs in maternal or cord serum, but 26-week maternal BPA was inversely associated with TSH in girls (-42.9%; 95% CI: -59.9, -18.5%), but not boys (7.6%; 95% CI: -17.3, 40.2%; p-for-effect modification=0.005) at birth. The inverse BPA-TSH relation among girls was stronger, but less precise, among iodine deficient versus sufficient mothers. Prenatal BPA exposure may reduce TSH among newborn girls, particularly when exposure occurs later in gestation.

Biomonitoring | A pilot study on the feasibility of European harmonized Human Biomonitoring: Strategies towards a common approach, challenges and opportunities. Next steps in European harmonization in Human Biomonitoring surveys include the establishment of a joint process for prioritization of substances to cover and biomarkers to develop, linking biomonitoring surveys with health examination surveys and with research, and coping with the diverse implementations of EU regulations and international guidelines with respect to ethics and privacy.

EDCs, cancer | Occupational exposure to endocrine disruptors and lymphoma risk in a multi-centric European study. We evaluated occupational exposure to endocrine disrupting chemicals (EDCs) among 2457 controls and 2178 incident lymphoma cases and subtypes from the European Epilymph study. Over 30 years of exposure to EDCs compared to no exposure was associated with a 24% increased risk of mature B-cell neoplasms (P-trend=0.02). Associations were observed among men, but not women.

Pesticides, male fertility | Fruit and vegetable intake and their pesticide residues in relation to semen quality among men from a fertility clinic. Consumption of fruits and vegetables with high levels of pesticide residues was associated with a lower total sperm count and a lower percentage of morphologically normal sperm among men presenting to a fertility clinic. Click here for a detailed explanatory synopsis about how “whether or not pesticide residue found in our diet is another factor that affects sperm quality is an important topic that needs further study”.

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