BPA and aggressive behaviour; flame retardants and premature birth; and more / Feb 2015 Science Digest #1 (human)

February 10, 2015 at 12:55 pm | Posted in News and Science Bulletins | Leave a comment
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February 2015 Science Digest #1:
Human Research

BPA, behaviour | Prenatal exposure to phthalate esters and behavioral syndromes in children at 8 years of age: Taiwan maternal and infant cohort study. Externalizing problem scores were significantly higher in association with a 1-unit increase in log10-transformed creatinine-corrected concentrations of maternal MBP (β = 4.29; 95% CI: 0.59, 7.99), MEOHP (β = 3.74; 95% CI: 1.33, 6.15), and MEHP (β = 4.28 ; 95% CI: 0.03, 8.26) after adjusting for the child’s sex, intelligence, and family income. Meanwhile, MBP and MEOHP were significantly associated with Delinquent Behavior and Aggressive Behavior scores. The same pattern was found for borderline and/or clinical ranges.

Organophosphates, semen quality | Associations between urinary organophosphate pesticide metabolite levels and reproductive parameters in men from an infertility clinic. Almost all OP pesticides are metabolized to at least one of six possible dialkylphosphates (DAPs). Despite wide use, their potential effects on human reproductive health have not yet been fully characterized. The aim of this study was to evaluate the associations between urinary concentrations of six DAP metabolites and reproductive parameters in men. Sperm concentration and TSC were both significantly inversely associated with DMP, DMDP, DMDTP and ∑DAP in multivariate analysis.

Asthma, environmental exposures | A systematic review of associations between environmental exposures and development of asthma in children aged up to 9 years. There was consistent evidence linking exposures to SHS, inhaled chemicals, mould, ambient air pollutants, some deficiencies in maternal diet and respiratory viruses to an increased risk for asthma (OR typically increased by 1.5-2.0). There was less consistent evidence linking exposures to pets, breast feeding and infant dietary exposures to asthma risk, and although there were consistent associations between exposures to antibiotics and paracetamol in early life, these associations might reflect reverse causation.

POPs, early menopause | Persistent organic pollutants and early menopause in US Women. This study of a representative sample of US women documents an association between EDCs and earlier age at menopause. We identified 15 EDCs that warrant closer evaluation because of their persistence and potential detrimental effects on ovarian function. Earlier menopause can alter the quantity and quality of a woman’s life and has profound implications for fertility, human reproduction, and our global society.

Flame retardants, premature birth | Does exposure to flame retardants increase the risk for preterm birth? Study quantifying PBDE-47, the most common congener in maternal plasma samples, collected at the time of labor from women who subsequently had term or preterm birth (PTB). Women with high (OR=3.8, CI: 1.6, 9.7; P=0.003) or very high PBDE-47 concentrations were at greater odds (OR=5.6, CI: 2.2, 15.2; P<0.001) for PTB than women with very low levels of PBDE-47.

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