Phthalates lower IQ; EDCs affect thyroid function // Jan 2015 Science Digest #1 (human research)

January 13, 2015 at 3:45 pm | Posted in News and Science Bulletins | Leave a comment
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January 2015 Science Digest #1:
Human Research

Phthalates, IQ | Persistent Associations between Maternal Prenatal Exposure to Phthalates on Child IQ at Age 7 Years. Child full-scale IQ was inversely associated with prenatal urinary metabolite concentrations of DnBP and DiBP: b = -2.69 (95% confidence interval [CI] = -4.33, -1.05) and b = -2.69 (95% CI = -4.22, -1.16) per log unit increase. Among children of mothers with the highest versus lowest quartile DnBP and DiBP metabolite concentrations, IQ was 6.7 (95% CI = 1.9, 11.4) and 7.6 (95% CI = 3.2, 12.1) points lower, respectively. Associations were unchanged after control for cognition at age 3 years.

BPA, blood pressure | Exposure to Bisphenol A From Drinking Canned Beverage Increases Blood Pressure: Randomized Crossover Trial. Urinary BPA concentration increased after consuming canned beverages by >1600% compared with that after consuming glass bottled beverages. Systolic blood pressure adjusted for daily variance increased by ≈4.5 mm Hg after consuming 2 canned beverages compared with that after consuming 2 glass bottled beverages, and the difference was statistically significant. The parameters of the heart rate variability did not show statistically significant differences. The present study demonstrated that consuming canned beverage and consequent increase of BPA exposure increase blood pressure acutely.

Endocrine disruptors, thyroid function | Endocrine disruption in human placenta: expression of the dioxin-inducible enzyme, cyp1a1, is correlated with that of thyroid hormone-regulated genes. In what the author elsewhere calls “the strongest evidence to date” that endocrine disrupting chemicals such as polychlorinated biphenyls (PCB), can interfere with thyroid hormone action in pregnant women. Here, pregnancies where the placenta contained higher levels of CYP1A1 also showed elevated levels of regulation of of two thyroid-regulated genes, even the mother’s overall thyroid hormone levels did not change (meaning the interference in thyroid function would be undetectable in conventional testing).

PCBs & pesticides, immune function | Potential effects of polychlorinated biphenyls (PCBs) and selected organochlorine pesticides (OCPs) on immune cells and blood biochemistry measures: a cross-sectional assessment of the NHANES 2003-2004 data. Study observing a significant association between PCB/OCP levels and blood markers in the general population. All of the levels were within normal ranges but the consistency of results may reflect subclinical effects. Largest differences were observed for NDL PCBs. Thus, routine application of toxic equivalency factors, which assume dioxin like mechanisms and aryl hydrocarbon receptor involvement, may not adequately reflect the effects of NDL PCBs in the mixture.

Endocrine disruptors, thyroid function | Prenatal exposure to endocrine disrupting chemicals in relation to thyroid hormone levels in infants – a Dutch prospective cohort study. Study finding that DDE and perfluorinated alkyl acids may be associated with T4 in a sex-specific manner. These results should however be interpreted with caution, due to the relatively small study population. More research is warranted, as studies on the role of environmental contaminants in this area are still limited.

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