High infant phthalate exposure in hospitals; sunscreen lowers fertility; and more // Dec 2014 science update #1

December 15, 2014 at 2:44 pm | Posted in Uncategorized | Leave a comment

December 2014 Science Digest #1:
Epidemiological Research

Phthalates, exposure | Phthalates and critically ill neonates: device-related exposures and non-endocrine toxic risks. Study finding that the daily intake of DEHP for critically ill preterm infants is on the order of 4,000 and 160,000 times higher than desired for avoiding reproductive and hepatic [liver-related] toxicities, respectively.

Sunscreen, male fertility | Urinary Concentrations of Benzophenone-Type Ultraviolet Radiation Filters and Couples’ Fecundity. Male partners’ concentrations of the UV filters BP-2 and 4-hydroxybenzophenone were associated with reduced fecundity in adjusted models (fecundability odds ratio (FOR) = 0.69 (95% confidence interval (CI): 0.50, 0.95) and FOR = 0.74 (95% CI: 0.54, 1.00), respectively). In models adjusting for both partners’ concentrations, male BP-2 concentration remained associated with reduced fecundity (FOR = 0.69, 95% CI: 0.49, 0.97). These data suggest that male exposure to select UV filters may diminish couples’ fecundity, resulting in a longer time to pregnancy.

Organophosphates, respiratory symptoms | Early-life Exposure to Organophosphate Pesticides and Pediatric Respiratory Symptoms in the CHAMACOS Cohort. Higher prenatal organophosphate (OP) exposures were non-significantly associated with respiratory symptoms in the previous 12 months at 5 or 7 years of age. This association was strongest for some OP compounds in the second half of pregnancy. Childhood OP concentrations were associated with respiratory symptoms and exercise-induced coughing in the previous 12 months at age 5 or 7 years.

Methodology, epidemiology | Thinking One Step Ahead: Strategies to Strengthen Epidemiological Data for Use in Risk Assessment. Risk assessment is a cornerstone of environmental health research and policy making. A commentary in this issue of EHP presents a set of recommendations and guidelines to help researchers more effectively characterize uncertainty in epidemiological findings. Not only will this provide more transparency for the science itself, says coauthor Jennifer Pierson, a scientific program manager at the ILSI Health and Environmental Sciences Institute, it should also lead to more sound policies when those findings are integrated into risk assessments.

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