Birth weight & PCB exposure; leukaemia & flame retardants; and more // Nov 2014 science digest #1

November 12, 2014 at 5:26 pm | Posted in News and Science Bulletins | Leave a comment
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November 2014 Science Digest #1:
Epidemiological Research

Birth Weight, PCBs | Prenatal exposure to PCB-153, p,p’-DDE and birth outcomes in 9000 mother-child pairs: Exposure-response relationship and effect modifiers. This study suggests that the association between low-level exposure to PCB-153 and birth weight exists and follows an inverse linear exposure-response relationship with effects even at low levels, and that maternal smoking and ethnicity modify this association.

Leukaemia, Flame Retardants | Residential Levels of Polybrominated Diphenyl Ethers and Risk of Childhood Acute Lymphoblastic Leukemia (ALL) in California. Study finding no association with ALL, the most common childhood cancer, for common PBDEs, but positive associations for specific octa and nonaBDEs. Additional studies with repeated sampling and biological measures would therefore be informative. Synopsis here. (“Up until a few years ago, nobody was even measuring them [octa- and nona-BDE congeners],” says Linda Birnbaum, director of the National Institute of Environmental Health Sciences.)

Asthma, BPA | Bisphenol A Exposure and the Development of Wheeze and Lung Function in Children Through Age 5 Years. A birth cohort study, enrolled during early pregnancy in the greater Cincinnati, Ohio, area among 398 mother-infant dyads. Two maternal urine samples were collected during pregnancy (at 16 and 26 weeks) and child urine samples annually to assess gestational and child BPA exposure. Results provide evidence suggesting that prenatal but not postnatal exposure to BPA is associated with diminished lung function and the development of persistent wheeze in children.

Behaviour, BPA | Prenatal Bisphenol A Exposure and maternally reported behavior in boys and girls. In analyses restricted to children of mothers with detectable prenatal urinary BPA (n=125), BPA was associated with moderately increased internalizing and externalizing behaviors, withdrawn/depressed behavior, somatic problems, and Oppositional/Defiant Disorder traits in boys.

Asthma, PFCs | Perfluoroalkyl Chemicals and Asthma among Children 12–19 Years of Age: NHANES (1999–2008). This cross-sectional study provides some evidence for associations between exposure to PFCs and asthma-related outcomes in children. The evidence is inconsistent, however, and prospective studies are needed.

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