Systematic review of pesticides as a cause of Non-Hodgkins Lymphoma; phthalates and obesity; and more // Sept 2014 science digest #1 (human)

September 21, 2014 at 2:02 pm | Posted in Uncategorized | Leave a comment

Sept. 2014 Science Digest #1 //
Human Research

Pesticides, Cancer | Non-Hodgkin lymphoma and occupational exposure to agricultural pesticide chemical groups and active ingredients: a systematic review and meta-analysis. In a handful of papers, associations between pesticides and NHL subtypes were reported; B cell lymphoma was positively associated with phenoxy herbicides and the organophosphorus herbicide glyphosate. Diffuse large B-cell lymphoma was positively associated with phenoxy herbicide exposure. Despite compelling evidence that NHL is associated with certain chemicals, this review indicates the need for investigations of a larger variety of pesticides in more geographic areas, especially in low- and middle-income countries, which, despite producing a large portion of the world’s agriculture, were missing in the literature that were reviewed.

BPA, reproduction | Bisphenol A and Reproductive Health: Update of Experimental and Human Evidence, 2007–2013. Based on reports that BPA impacts female reproduction and has the potential to affect male reproductive systems in humans and animals, this review concludes that BPA is a reproductive toxicant. (See a presentation of the strengths and weaknesses of this review here.)

Perchlorate, thyroid function | Maternal perchlorate levels in women with borderline thyroid function during pregnancy and the cognitive development of their offspring; Data from the Controlled Antenatal Thyroid Study. This is the first study using individual-level patient data to study maternal perchlorate exposure and offspring neurodevelopment and suggests that high-end maternal perchlorate levels in hypothyroid/hypothyroxinemic pregnant women have an adverse effect on offspring cognitive development, not affected by maternal levothyroxine therapy. (Perchlorate is a component of rocket fuel.)

Phthalates, fertility | Urinary Phthalate Metabolites Are Associated With Decreased Serum Testosterone in Men, Women, and Children From NHANES 2011-2012. Study exploring relationships between urinary concentrations of 13 phthalate metabolites and serum total T levels among men, women, and children. In boys 6-12 years old, an interquartile range increase in metabolites of di-2-ethylhexyl phthalate was associated with a 29% (95% confidence interval, 6, 47) reduction in testosterone.

Phthalates, obesity | Age and Sex-Specific Relationships between Phthalate Exposures and Obesity in Chinese Children at Puberty. Study reporting age and sex-specific concentration-effect associations between phthalate exposure and fat distribution in Chinese children. Urinary phthalate levels in 11-13 yrs boys were about 30 percent higher than those in girls, and ∑MEHP levels in younger boys (<10 yrs) were significantly higher than those in elder boys (>10 yrs). Associations were positive for MBP and ∑LMP with both BMI z-score and fat distribution in boys >10 years of age, and negative for ∑MEHP with fat distribution in girls <10 years of age.

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