Effect of PFC exposure on thyroid levels in pregnancy; PCBs on hearing; and more // August 2014 science digest #1

August 10, 2014 at 2:44 pm | Posted in News and Science Bulletins | Leave a comment
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August Science Digest #1
Human research

Thyroid function, PFCs | Associations between perfluoroalkyl acids (PFASs) and maternal thyroid hormones in early pregnancy: A population-based cohort study. PFASs were positively associated with thyroid stimulating hormone and weakly negatively associated with free thyroxine in the subset of pregnant women with high thyroid peroxidase antibody, a marker of autoimmune hypothyroidism and which occurs in 6-10% of pregnancies. PFASs may exacerbate the already high TSH and low fT4 levels in these women during early pregnancy, which is a critical time of thyroid hormone-mediated fetal brain development; however, the clinical significance of these findings is not clear.

Hearing, PCBs | Prenatal and Postnatal Serum PCB Concentrations and Cochlear Function in Children at 45 Months of Age. Study finding an association between poorer performance in hearing tests and postnatal exposure to PCBs; maternal and cord PCB concentrations were not associated with hearing performance.

Obesity, BPA || Early-Life Bisphenol A Exposure and Child Body Mass Index: A Prospective Cohort Study. To determine if early life BPA exposure was associated with increased body mass index (BMI) at 2-5 years of age, 297 mother-child pairs were studied (HOME Study). Prenatal and early childhood BPA exposures were not associated with increased BMI at 2-5 years, but higher early childhood exposure to BPA was associated with accelerated growth during this period.

Brain cancer, solvents | Childhood brain tumours: associations with parental occupational exposure to solvents. An increased risk of childhood brain tumor (CBT) was observed with maternal occupational exposures to chlorinated solvents (OR=8.59, 95% CI 0.94–78.9) any time before birth. Paternal exposure to solvents in the year before conception was also associated with an increased CBT risk: OR=1.55 (95% CI 0.99–2.43). This increased risk appeared to be mainly attributable to exposure to aromatic solvents: OR=2.72 (95% CI 0.94–7.86) for benzene and OR=1.76 (95% CI 1.10–2.82) for other aromatics.

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