Higher PFOA, lower birth weight; abandoning gavage; and more // June science digest #2 (nonhuman and policy research)

July 8, 2014 at 12:45 pm | Posted in News and Science Bulletins | Leave a comment
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June Science Digest #2:
Nonhuman and policy research

Foetal development, PFOA | Systematic Review of Nonhuman Evidence for PFOA Effects on Fetal Growth. Analysis of twenty-one studies yields an estimate that exposure of pregnant mice to increasing concentrations of PFOA is associated with a decrease in mean pup birth weight of -0.023g (95% CI: -0.029, -0.016) per 1-unit increase in dose (mg/kg BW/day), providing evidence that PFOA does affect foetal development in the animal model.

Research methods, EDCS | Should oral gavage be abandoned in toxicity testing of endocrine disruptors? Review enumerating several reasons why gavage is not appropriate for the assessment of EDCs using bisphenol A (BPA) as a main example. For example, whereas human dietary exposures interact with the oral mucosa, gavage exposures avoid these interactions, leading to dramatic differences in absorption, bioavailability and metabolism with implications for toxicokinetic assumptions and models.

Neural development, BPA | Newborn mice exposed prenatally to bisphenol A show hyperactivity and defective neocortical development. Observations of newborn mice prenatally exposed to 20 and 200 micrograms BPA kg/day revealed abnormal neuronal distribution and layer formation, hypoplasia of layer 6b, and abnormal dopaminergic neuronal projections in the neocortex. Further, the newborn mice exhibited hyperactivity. These findings suggest that prenatal BPA exposure induces neurobehavioral toxicity associated with abnormal dopaminergic neuronal projections, and abnormal corticogenesis and lamination.

Diabetes, BPA | Exposure to Bisphenol-A during Pregnancy Partially Mimics the Effects of a High-Fat Diet Altering Glucose Homeostasis and Gene Expression in Adult Male Mice. The group of mice exposed to BPA started to gain weight at 18 weeks old and caught up to the mice on a high-fat diet before week 28. The BPA group as well as the HFD and HFD-BPA ones presented fasting hyperglycemia, glucose intolerance and high levels of non-esterified fatty acids (NEFA) in plasma compared with the Control one. Glucose stimulated insulin release was disrupted, particularly in the HFD-BPA group.


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