PFCs and asthma, phthalate exposure and pre-term birth, plus more // June 2014 science digest #1 (human research)

July 7, 2014 at 11:25 am | Posted in News and Science Bulletins | Leave a comment
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June Science Digest #1:
Human Research

Neonatal phthalate exposure in healthcare environments | A Longitudinal Study of Urinary Phthalate Excretion in 58 Full-Term and 67 Preterm Infants from Birth through 14 Months. In this study of hospitalised neonates, the majority of PT (80%) infants and approximately one third of healthy FT newborns (30%) were exposed to phthalates during early life at a potentially harmful level according to EFSA’s recommended limits on daily exposure (a level set for adults).

Child phthalate exposure in educational environments | Phthalate Exposure and Risk Assessment in California Child Care Facilities. Approximately 13 million U.S. children less than 6 years old spend some time in early childhood education (ECE) facilities. The results of this risk assessment indicate that between 8 and 9 children out of 10 in California ECE facilities are exposed to dibutyl phthalate at levels exceeding reproductive health benchmarks, and about 1 in 10 children less than 2 years old are exposed to DEHP at levels exceeding cancer benchmarks.

Childhood asthma, PFCs | Perfluoroalkyl Chemicals and Asthma among Children 12-19 Years of Age: NHANES (1999-2008). This cross-sectional study provides some evidence for associations between exposure to PFCs and asthma-related outcomes in children: in multivariable adjusted models, PFOA was associated with higher odds of ever having received a diagnosis of asthma, whereas for PFOS there were inverse relationships with both asthma and wheezing..

Autism, pesticide exposure | Neurodevelopmental Disorders and Prenatal Residential Proximity to Agricultural Pesticides: The CHARGE Study. Gestational exposure to several common agricultural pesticides can induce developmental neurotoxicity in humans, and has been associated with developmental delay and autism. This study of ASD strengthens the evidence linking neurodevelopmental disorders with gestational pesticide exposures, and particularly, organophosphates and provides novel results of ASD and DD associations with, respectively, pyrethroids and carbamates. (Coverage in Scientific American.)

Pre-term birth, phthalates | Variability in urinary phthalate metabolite levels across pregnancy and sensitive windows of exposure for the risk of preterm birth. Urinary phthalate metabolite levels were moderately variable over pregnancy. Nonetheless, levels measured at various time points were associated with increased odds of preterm birth, the strongest associations being measured at the beginning of the third trimester.

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