April 2014 Science Digest #2: Non-human toxicological and policy research

April 14, 2014 at 9:01 am | Posted in News and Science Bulletins | Leave a comment
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Flame Retardants, Diabetes | Impaired Lipid and Glucose Homeostasis in Hexabromocyclododecane-Exposed Mice Fed a High-Fat Diet. Results: In HFD-fed mice, body weight was increased in mice treated with the high and medium doses of HBCD compared with vehicle. These increases were paralleled by increases in random blood glucose and insulin levels. This suggests that HBCD may contribute to enhancement of diet-induced body weight gain and metabolic dysfunction.

Parabens, Exposures and Effects | Parabens. From environmental studies to human health. Parabens are a group of substances commonly employed as preservatives, mainly in personal care products, pharmaceuticals and food. Scientific reports concerning their endocrine disrupting potential and the possible link with breast cancer raised wide discussion about parabens’ impact and safety. This paper provides holistic overview of paraben usage, occurrence in the environment, methods of their degradation and removal from aqueous solution, as well as hazards related to their endocrine disrupting potential and possible involvement in carcinogenesis.

BPA, General Toxicity | Toxicity Evaluation of Bisphenol A Administered by Gavage to Sprague Dawley Rats From Gestation Day 6 Through Postnatal Day 90. The recent FDA study which found no evidence of BPA toxicity at low doses. Questions have been raised about the appropriateness of end-points (no neurotoxicity assays), BPA contamination of control animals, and the whether the length of study was sufficient.

BPA, Mammary Effects | Prenatal Bisphenol A exposure delays the development of the male rat mammary gland. On PND30, the exposure to 64BPA and 250BPA induced a delay in male MG development, evidenced by reduced ductal growth, decreased number of terminal structures and lower expression of androgen receptor (AR). In contrast, female mammary ductal growth was altered only by 250BPA. Regardless of the administration route and length of the exposure period, BPA induced a delay in MG development and modified AR expression in prepubertal male rats.

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