April 2014 Science Digest #1: Recent Epidemiological Research

April 7, 2014 at 5:13 pm | Posted in News and Science Bulletins | Leave a comment
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Phthalates, Exposure | Examination of temporal Trends in Phthalate Exposures: Findings from the National Health and Nutrition Examination Survey, 2001–2010. Examination of temporal trends in urinary concentrations of phthalate metabolites in the general U.S. population and whether trends vary by sociodemographic characteristics. Finds substantial differences in current exposures in comparison to historical exposures.

POPs, Behaviour | Behavioral Sexual Dimorphism in School-Age Children and Early Developmental Exposure to Dioxins and PCBs: A Follow-Up Study of the Duisburg Cohort. The authors conclude that, given their results and the findings of previous studies, there is sufficient evidence that these EDCs modify behavioral sexual dimorphism in children, “presumably by interacting with the hypothalamic–pituitary–gonadal axis”.

PAHs, Obesity | Urinary Polycyclic Aromatic Hydrocarbons and Childhood Obesity: NHANES (2001–2006). BMI z-score, waist circumference and obesity were positively associated with the molecular mass sum of the PAHs and the total sum of naphthalene metabolites. Most associations increased monotonically with increasing quartiles of exposure among children 6–11 years of age, whereas dose–response trends were less consistent for adolescents (12–19 years of age).

BPA, Phthalates, Fertility | Urinary bisphenol A, phthalates, and couple fecundity: the Longitudinal Investigation of Fertility and the Environment (LIFE) Study. Select male but not female phthalate exposures were associated with an approximately 20% reduction in fecundity, underscoring the importance of assessing both partners’ exposure to minimize erroneous conclusions.

Metabolic Disorders, PFCs | Adiposity and Glycemic Control in Children Exposed to Perfluorinated Compounds. Discussion: Increased PFC exposure in overweight 8- to 10-year-old children was associated with higher insulin and triglyceride concentrations. Chance findings may explain some of our results, and due to the cross-sectional design, reverse causation cannot be excluded. The findings therefore need to be confirmed in longitudinal studies.

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