Feb 2014 science digest #2: recent non-human and policy research

February 9, 2014 at 2:33 pm | Posted in News and Science Bulletins | Leave a comment

Research Quality | A Valuable Contribution toward Adopting Systematic Review in Environmental Health. Summary of four ways in which a recent review of tools for appraising the methodological quality of animal studies is of service to the US EPA’s IRIS programme. Also of interest is an article in Nature, detailing the US NIH’s plans to enhance the reproducibility of research.

BPA, Prostate Cancer | Bisphenol A Promotes Human Prostate Stem-Progenitor Cell Self-Renewal and Increases In Vivo Carcinogenesis in Human Prostate Epithelium. Exposure to low levels of bisphenol A during development may make men more susceptible to prostate cancer later in life, according to this study, which uses a new model of implanting human stem cells into mice. It links early-life BPA exposure to human prostate cancer. Synopsis here.

BPA, Metabolism | Metabolomic Analysis Reveals Metabolic Changes Caused By Bisphenol A in Rats. This study concludes that elevated choline metabolism underlies the mechanism of highly-methylated environmental and related metabolic alterations caused by BPA. These biomarkers of injury indicate that BPA induces DNA methylation damage and broad protein degradation, and the increase in deleterious metabolites in the choline pathway may also be involved in the toxicity of BPA.

BPA, Testicular Function | Bisphenol A regulation of testicular endocrine function in male rats is affected by diet. These findings imply that interaction between BPA and a high fat diet may cause a greater degree of testicular dysfunction than either BPA exposure or HFD consumption alone.

BPA, Health Costs | Further limiting bisphenol a in food uses could provide health and economic benefits. This article quantifies estimates that in 2008 BPA exposure was to be associated with 12,404 cases of childhood obesity and 33,863 cases of newly incident coronary heart disease, with estimated social costs of $2.98 billion. Removing BPA from food uses might prevent 6,236 cases of childhood obesity and 22,350 cases of newly incident coronary heart disease per year.

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