January 2014 science digest #1: recent human research highlights

January 9, 2014 at 4:56 pm | Posted in News and Science Bulletins | Leave a comment

Pesticides, Behaviour | Urinary Metabolites of Organophosphate and Pyrethroid Pesticides and Behavioral Problems in Canadian Children. Pyrethroids are insecticides rapidly gaining popularity but epidemiological evidence on their potential effects is lacking. In contrast with previous studies, this study did not observe an association between exposure to organophosphate pesticides and behavioral scores in children. However, some pyrethroid urinary metabolites were associated with a high level of parent-reported behavioral problems.

PFCs, Diabetes | Incidence of type II diabetes in a cohort with substantial exposure to perfluorooctanoic acid. Cross-sectional study not finding an association between PFOA exposure and incidence of type II diabetes.

PCBs, Cardiovascular Disease | Analysis of the effects of exposure to polychlorinated biphenyls and chlorinated pesticides on serum lipid levels in residents of Anniston, Alabama. Increased concentrations of PCBs and organochlorine pesticides are associated with elevations in total serum lipids, total cholesterol and triglycerides, but the patterns are different for different groups of PCBs and different pesticides. These observations show selective effects of different organochlorines on serum concentrations of different groups of lipids. This elevation in concentrations of serum lipids may be the basis for the increased incidence of cardiovascular disease found in persons with elevated exposures to PCBs and chlorinated pesticides.

Organochlorines, Sexual Development | Hypospadias in offspring is associated with chronic exposure of parents to organophosphate and organochlorine pesticides. Study supporting the hypothesis that organophosphate and organochlorine pesticide exposure may be a potential risk factor for hypospadias.

BPA, Review | Bisphenol A and human chronic diseases: Current evidences, possible mechanisms, and future perspectives. In this review, the authors present evidence on the relationship between BPA exposure and human chronic diseases and discuss its eventual mechanisms of action, especially genetic, epigenetic and endocrine disruption mechanisms, along with the possible involvement of oxidative stress, mitochondrial dysfunction and cell signaling.

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