Research digest (Nov 2013): Recent highlights in human epidemiology and other studies

November 18, 2013 at 4:29 pm | Posted in News and Science Bulletins | Leave a comment

Human research

Phthalates, Allergy | Phthalate Exposure and Allergy in the U.S. Population: Results from NHANES 2005–2006. In this cross-sectional analysis of a nationally representative sample, high molecular weight phthalate metabolites, particularly MBzP, were positively associated with allergic symptoms and sensitization in adults. There was no strong evidence for associations between phthalates and allergy in children 6–17 years of age.

Cosmetics, Fertility | Urinary Glycol Ether Metabolites in Women and Time to Pregnancy: The PELAGIE Cohort. Phenoxyacetic acid, present in most of the urine samples tested in this study, was associated with increased time to pregnancy. This metabolite and its main parent compound (2-phenoxyethanol) are either plausible causes of decreased fecundability, or they are surrogates for coexposures to compounds frequently present in cosmetics.

POPs, Development | Maternal dietary intake of dioxins and polychlorinated biphenyls and birth size in the Norwegian Mother and Child Cohort Study. Dietary intakes of dioxins and PCBs during pregnancy were negatively associated with fetal growth, even at intakes below the tolerable weekly intake.

Organophosphates, Neurotoxicity | Neurodevelopmental effects in children associated with exposure to organophosphate pesticides: A systematic review. The studies reviewed here support the hypothesis that exposure to OP pesticides induces neurotoxic effects. Further research is needed to understand effects associated with exposure in critical windows of development.

Chemicals, Development | ACOG: Exposure to Toxic Environmental Agents. The evidence that links exposure to toxic environmental agents and adverse reproductive and developmental health outcomes is sufficiently robust, and the American College of Obstetricians and Gynecologists and the American Society for Reproductive Medicine join leading scientists and other clinical practitioners in calling for timely action to identify and reduce exposure to toxic environmental agents while addressing the consequences of such exposure.  (Click here for our coverage of the statement.)

Phthalates, Fertility | Human urinary phthalate metabolites level and main semen parameters, sperm chromatin structure, sperm aneuploidy and reproductive hormones. Urinary phthalate metabolites levels were significantly associated with a decrease in sperm motility (5OH MEHP, MEHP, MINP), CASA parameters (MBP), testosterone level (MEHP) and an increase sperm DNA damage (MBP) and sperm aneuploidy (MBzP, MBP, MEHP, MEP).

Other research

Flame retardants, Endocrine Disruption | Mimicking of Estradiol Binding by Flame Retardants and Their Metabolites: A Crystallographic Analysis. Using X-ray crystallography, these researchers obtained atomic detail of the binding modes of TBBPA and 3-OH-BDE-47 to estrogen sulfotransferase, showing how brominated flame retardants or their metabolites can bind to and inhibit a key hormone-metabolizing enzyme, potentially causing endocrine disruption.

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