Research digest #1 (Oct 2013) // Recent human studies of chemical toxicity

October 15, 2013 at 8:26 am | Posted in News and Science Bulletins | Leave a comment
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The Human Urine Metabolome. Urine has long been a “favored” biofluid among metabolomics researchers. After 7 years’ work, an online database containing the complete set of 2651 confirmed human urine metabolite species, their structures (3079 in total), concentrations, related literature references and links to their known disease associations has now been developed.

Phthalates and the diets of US children and adolescents. Diet contributes to urinary phthalate concentrations in children and adolescents. Further study is needed to examine the implications of di-2-ethylhexylphthalate exposure, especially earlier in life, when more permanent metabolic changes may occur.

Human exposures to bisphenol A: mismatches between data and assumptions. The conflict between reported data and toxicokinetic models has spurred considerable debate, with some suggesting that data from analyses of human blood should be dismissed in their entirety. To the contrary, this review considers evidence that challenges the assumption that humans metabolize BPA rapidly enough to result in undetectable levels in blood, to therefore determine that there is a possibility of harm from current exposure levels.

Prenatal Exposure to Persistent Organochlorines and Childhood Obesity in the U.S. Collaborative Perinatal Project. This study evaluated the association of maternal serum levels of β-hexachlorocyclohexane (β-HCH), p,p´-DDE, dichlorodiphenyltrichloroethane (p,p´-DDT), dieldrin, heptachlor epoxide, HCB, trans-nonachlor, oxychlordane, and PCBs with offspring obesity during childhood. No clear associations with obesity or BMI emerged.

Association between Perfluoroalkyl substances and thyroid stimulating hormone among pregnant women: a cross-sectional study. Results of this study suggest an association between PFOS and TSH in pregnant women that is small and may be of no clinical significance.

Bisphenol A and Human Health: A review of the literature. This review discusses the growing human literature correlating environmental BPA exposure to adverse effects in humans which, along with laboratory studies in many species including primates, it argues provides increasing support that environmental BPA exposure can be harmful to humans, especially in regards to behavioral and other effects in children.

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