Research digest (Sept 2013) // Recent human studies of chemical toxicity

September 10, 2013 at 4:20 pm | Posted in News and Science Bulletins | Leave a comment
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Phthalates, Diabetes. Urinary Phthalates and Increased Insulin Resistance in Adolescents In Pediatrics. Urinary DEHP concentrations were associated with increased insulin resistance in this cross-sectional study of adolescents. This study cannot rule out the possibility that insulin-resistant children ingest food with higher phthalate content, or that insulin-resistant children excrete more DEHP.

Exposure, BPA. BPA, BPA glucuronide, and BPA sulfate in mid-gestation umbilical cord serum in a northern California cohort. Findings suggest universal fetal exposure to BPA in our study population, with some at relatively high levels, and we provide the first evidence of detectable BPA sulfate in mid-gestation fetuses. Levels were highly variable.

Autoimmune, PFCs. Ulcerative Colitis and Perfluorooctanoic Acid (PFOA) in a Highly Exposed Population of Community Residents and Workers in the Mid-Ohio Valley. Incidence of ulcerative colitis was significantly increased in association with PFOA exposure, with adjusted rate ratios by quartile of exposure of 1.00 (referent), 1.76 (95% CI: 1.04, 2.99), 2.63 (95% CI: 1.56, 4.43), and 2.86 (95% CI: 1.65, 4.96) (ptrend < 0.0001). A prospective analysis of ulcerative colitis diagnosed after the baseline 2005–2006 survey (n = 29 cases) suggested a positive but non-monotonic trend (ptrend = 0.21).

Developmental health, PFCs. Serum Perfluorooctanoic Acid and Perfluorooctane Sulfonate Concentrations in Relation to Birth Outcomes in the Mid-Ohio Valley, 2005-2010. Results provide some evidence of positive associations between measured serum perfluorinated compounds and pregnancy-induced hypertension and a negative association between PFOS and birth weight among full-term infants.

Neurotoxicity, POPs. Prenatal exposure to polychlorinated biphenyls and their hydroxylated metabolites is associated with motor development of three-month-old infants. Prenatal exposure to high background levels of most PCBs and 4-OH-PCB-107 seems to impair early motor development, whereas only 4′-OH-PCB-172 showed the opposite.

Review, Parabens. Parabens: Potential impact of Low-Affinity Estrogen receptor Binding chemicals on Human health. A number of recent reports suggest that parabens pose a negligible endocrine-disrupting risk. However, people are not routinely exposed to a single paraben, and most of the available paraben toxicity data are from single-exposure studies. This review discusses knowledge gaps and research and policy requirements.

Diabetes, Dioxins. Diabetes, Metabolic Syndrome, and Obesity in Relation to Serum Dioxin Concentrations: The Seveso Women’s Health Study. Finds an increased prevalence of metabolic syndrome associated with TCDD, but only among women who were the youngest at the time of the Seveso incident. Continued follow-up of the SWHS cohort will be informative.

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