August research digest #1: Recent human research into health effects of chemical exposure

August 8, 2013 at 11:13 am | Posted in News and Science Bulletins | 1 Comment

Diabetes / cohdra, Morguefile

Diabetes / POPs. Evaluation of the Association between Persistent Organic Pollutants (POPs) and Diabetes in Epidemiological Studies: A National Toxicology Program Workshop Review. A review of 72 studies found the overall evidence is sufficient for a positive association of some organochlorine POPs with type 2 diabetes (though heterogeneity of data precluded meta-analysis). The strongest correlations were observed for organochlorine compounds.

Neurotoxicity / BPA. Prenatal and early childhood bisphenol A concentrations and behavior in school-aged children. Prenatal urinary BPA concentrations were associated with increased internalizing problems in boys, including anxiety and depression, at age 7. Childhood urinary BPA concentrations were associated with increased externalizing behaviors, including conduct problems, in girls at age 7 and increased internalizing behaviors, inattention and hyperactivity in both boys and girls at age 7.

Thyroid function / PFCs. Association Between Serum Perfluorinated Chemicals and Thyroid Function in U.S. Adults: The National Health and Nutrition Examination Survey 2007–2010. Using NHANES data, this study finds that higher serum concentrations of PFOA and PFHxS are associated with total T3, total T4, and free T4 in the U.S. general population.

Cancer (NHL) / Benzene. Residence proximity to benzene release sites is associated with increased incidence of non-Hodgkin lymphoma. For every mile further away from benzene release sites, there was a 0.31% decrease in the risk of NHL. Similar results were observed for all NHL subtypes analyzed.

Cardiovascular / POPs. Associations between plasma persistent organic pollutant levels and blood pressure in Inuit adults from Nunavik. Some PCB congeners were associated with higher risk of hypertension in this highly exposed population. Most associations became significant after including n-3 PUFAs in the models. However, the analyses of OC pesticides revealed divergent results, which need to be confirmed in further cohort and experimental studies.

Mental health / Pesticides. Pesticide Exposure and Depression Among Agricultural Workers in France. The hazard ratio for depression among those who used herbicides was 1.93 (95% confidence interval (CI): 0.95, 3.91); there was no association with insecticides or fungicides. Compared with nonusers, those who used herbicides for <19 years and ≥19 years (median for all herbicide users, 19 years) had hazard ratios of 1.51 (95% CI: 0.62, 3.67) and 2.31 (95% CI: 1.05, 5.10), respectively.

Cancer (NHL) / TCE. Occupational exposure to trichloroethylene and risk of non-Hodgkin lymphoma and its major subtypes: a pooled Inter-Lymph analysis. Pooled analysis supporting the hypothesis of an increase in risk of specific NHL subtypes associated with occupational exposure to TCE.

Musculoskeletal / POPs. Dioxin-like compounds and bone quality in Cree women of Eastern James Bay (Canada): a cross-sectional study. Results show a negative association between a measure of bone strength and increases in plasma concentrations of dioxin-like PCBs 105 and 118.

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  1. […] August research digest #1 for human epidemiological […]


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