5&5: News and science highlights from June 2013

July 9, 2013 at 5:52 pm | Posted in News and Science Bulletins | Leave a comment
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Science

Bisphenol A Exposure during Adulthood Causes Augmentation of Follicular Atresia and Luteal Regression by Decreasing 17β-Estradiol Synthesis via Downregulation of Aromatase in Rat Ovary. Adult rats exposed orally to low doses of BPA showed significantly decreased serum concentration of 17-beta-estradiol, which disturbed the maintenance of normal ovarian function. Two steroidogenic proteins were also apparently targeted by BPA.

Consumer-perceived risks and choices about pharmaceuticals in the environment: a cross-sectional study. “It can be concluded that the environmental impact of a drug will be hardly considered in decisions about pharmaceuticals for severe diseases like cancer, and this may be due to the fact that these decisions are predominantly affective in nature. However, for less severe health risks, people are willing to balance health and environmental considerations.”

Mutagenic effect of Bisphenol A on adult rat male germ cells and their fertility. Male rats dosed orally with 5.0mg/kgbw/day showed an increase in sperm DNA damage, decrease in testicular daily sperm production, and epididymal sperm count and motility. This suggests that BPA may be a weak male germ cell mutagen.

Glyphosate induces human breast cancer cells growth via estrogen receptors. Study on the effects of pure glyphosate on estrogen receptor mediated transcriptional activity and their expressions. Finds that glyphosate exerted proliferative effects in human hormone-dependent breast cancer, T47D cells.

Regulatory decisions on endocrine disrupting chemicals should be based on the principles of endocrinology. A discussion of why the study and regulation of EDCs should incorporate endocrine principles; what level of consensus there is for low dose effects; challenges to our understanding of non-monotonicity; and whether EDCs have been demonstrated to produce adverse effects.

News

Report on chemical exposure is criticised for panicking pregnant women. The BMJ describes how the Royal College of Obstetrics and Gynaecology found itself in the firing line over a report about how chemical exposure might be an issue of concern for pregnant women (RCOG’s response is here). The UK Daily Mail provided what was probably the most balanced of the mainstream media coverage, giving space to RCOG’s arguments as well as the negative reactions.

Science should focus on ‘new’ environmental health risks, EU report says. Europeans live longer, healthier lives partly due to successful environmental policies on air, water and food, according to a new report. However, several new health risks are emerging from new chemicals, products and changing lifestyle patterns, an EU report says.

Reality check on TSCA reform legislation. The Environmental Defense Fund explain their controversial support for proposed TSCA reforms, saying the no prior draft of the TSCA reforms “got further than a Senate committee’s approval on a strictly party-line vote. That means there is simply no basis for talking about what has been ‘lost’ from the current bipartisan legislation – for the simple reason that you can’t lose what you never had.”

OECD defends GLP against claims it impedes advancing science. A lengthy argument against the claim that requiring OECD/GLP compliant studies results in non-compliant studies being ignored. Although the advantages of a standardised test system are well-articulated, the article does not touch on whether the existence of standards leads to non-standard studies being unnecessarily down-graded in quality and discarded from the RA process.

Scientists defend WHO/UNEP EDC report. Scientists who authored the recent state-of-the-science report on endocrine disrupting chemicals for the UN Environment Programme and the World Health Organization, have responded strongly to criticisms of their report by the International Council of Chemical Associations (critical ICCA letter here; authors’ response not available on-line).

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