Six recent human environmental health studies

May 7, 2013 at 2:36 pm | Posted in News and Science Bulletins | Leave a comment

Prenatal and Postnatal Bisphenol A Exposure and Body Mass Index in Childhood in the CHAMACOS Cohort. The first prospective study to estimate effects of prenatal and early-life exposure to bisphenol A (BPA) on children’s body mass has found that girls who were exposed to the highest concentrations in utero had lower weight for their height and were less likely to be obese at age 9 than girls with the lowest exposures. However, the same was not true of boys, and a cross-sectional analysis of both sexes at age 9 showed a positive association between current BPA urinary concentrations and obesity.

Urinary Bisphenol A and Obesity in US Children. Examination of an association between urinary BPA and obesity in children aged 6-18 years from NHANES. It finds a positive association between increasing levels of urinary BPA and obesity, independent of age, sex, race/ethnicity, education, physical activity, serum cotinine, and urinary creatinine.

Association of Osteoarthritis with Perfluorooctanoate and Perfluorooctane Sulfonate in NHANES 2003–2008. Higher concentrations of serum PFOA were associated with osteoarthritis in women, but not men. PFOS was also associated with osteoarthritis in women only, though effect estimates for women were not significant. More research is needed to clarify potential differences in susceptibility between women and men with regard to possible effects of these and other endocrine-disrupting chemicals.

Associations of in Utero Exposure to Perfluorinated Alkyl Acids with Human Semen Quality and Reproductive Hormones in Adult Men. This investigation of whether in utero exposure to PFOA and PFOS affects semen quality, testicular volume, and reproductive hormone levels, suggests that in utero exposure to PFOA is associated with lower adjusted sperm concentration and total sperm count, and with higher adjusted levels of luteinizing hormone and follicle-stimulating hormone. PFOS did not appear to be associated with any of the outcomes assessed.

Serum Polyfluoroalkyl Concentrations, Asthma Outcomes, and Immunological Markers in a Case–Control Study of Taiwanese Children. This study suggests an association between PFC exposure and juvenile asthma. Because of widespread exposure to these chemicals, these findings may be of potential public health concern.

Circulating levels of persistent organic pollutants (POPs) are associated with left ventricular systolic and diastolic dysfunction in the elderly. Circulating levels of POPs were related to impairments in both left ventricular systolic and diastolic function independently of major congestive heart failure risk factors, suggesting a possible role of POPs in heart failure.

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