Six recent human environmental health studies

April 16, 2013 at 10:56 am | Posted in News and Science Bulletins | Leave a comment
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Associations of in Utero Exposure to Perfluorinated Alkyl Acids with Human Semen Quality and Reproductive Hormones in Adult Men. This investigation of whether in utero exposure to PFOA and PFOS affects semen quality, testicular volume, and reproductive hormone levels, suggests that in utero exposure to PFOA is associated with lower adjusted sperm concentration and total sperm count, and with higher adjusted levels of luteinizing hormone and follicle-stimulating hormone. PFOS did not appear to be associated with any of the outcomes assessed.

Prenatal and Postnatal Bisphenol A Exposure and Body Mass Index in Childhood in the CHAMACOS Cohort. The first prospective study to estimate effects of prenatal and early-life exposure to bisphenol A (BPA) on children’s body mass has found that girls who were exposed to the highest concentrations in utero had lower weight for their height and were less likely to be obese at age 9 than girls with the lowest exposures. However, the same was not true of boys, and a cross-sectional analysis of both sexes at age 9 showed a positive association between current BPA urinary concentrations and obesity.

Phthalate exposure and children’s health. Several epidemiological studies suggest fetal and childhood exposure to some phthalates may perturb normal development, with several studies consistently reporting increased risk of allergic diseases with DEHP and BBzP exposure. Although anticipatory guidance is not evidence-based at this time, providers can counsel concerned patients to reduce phthalate exposures in order to protect the developing fetus and child from potential adverse health outcomes.

Potential Sources of Bisphenol A in the Neonatal Intensive Care Unit. The authors describe nasal oxygen administration and continuous positive airway pressure as individual sources of higher exposure to BPA. In those circumstances, BPA would be delivered into the lungs and pass into the circulation without undergoing first-pass metabolism in the liver. Thus, exposures to free, active BPA would be higher than if the same amount had been ingested.

Exposure to an Organochlorine Pesticide (Chlordecone) and Development of 18-Month-Old Infants. Results suggest that prenatal exposure to chlordecone is associated with specific impairments in fine motor function in boys, and add to the growing evidence that exposure to organochlorine pesticides early in life impairs child development.

Association of Osteoarthritis with Perfluorooctanoate and Perfluorooctane Sulfonate in NHANES 2003–2008. Higher concentrations of serum PFOA were associated with osteoarthritis in women, but not men. PFOS was also associated with osteoarthritis in women only, though effect estimates for women were not significant. More research is needed to clarify potential differences in susceptibility between women and men with regard to possible effects of these and other endocrine-disrupting chemicals.

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