Follow-up: More on how “weak” oestrogen BPA can act as a powerful endocrine disruptor

July 17, 2009 at 4:58 pm | Posted in Briefing | Leave a comment
John Peterson Myers

John Peterson Myers

Pete Myers, founder and CEO of Environmental Health Sciences and author of Our Stolen Future, helpfully pointed out a couple items (one from 2002) which follow the same line of thought we expressed in proposing a mechanism for how BPA can act as a powerful endocrine disruptor.

So in case you were wondering, the science isn’t that new. And is a great site – it isn’t exactly aesthetic, but there is a lot of great content. Over to Pete:

We’ve been covering this mechanism on and since 2002. Here is one example: BPA is not a weak estrogen.

What is of special interest is that the gene cascade which is initiated by phosphorylation of the transcription factor CREB, among other things, upregulates a gene central to converting stem cells into fat cells, and it also is involved in disregulation of insulin. Here’s where this work started.

The article in second link points out four key lessons from the CREB research from 2002 (it’s well worth noting this research is now seven years old, yet there is still very little action being taken to control public exposure to BPA, with most food safety bodies adament that low levels of the chemical pose no risk to health):

  1. It involves a new type of estrogen receptor, located on the surface of the cell membrane.
  2. It finds bisphenol A to be just as powerful as estradiol in binding with this new receptor.
  3. Binding and alteration of gene expression occurs at extremely low levels, low parts per billion, well within the range of bisphenol A [levels] found in people today.
  4. By activating the transcription factor CREB, bisphenol A has the potential of altering gene expression in several profoundly important systems that are vital for normal development and functioning.

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